Pandemics pose an inarguably daunting global threat: they are hard to predict, spread globally at rapid speed, impact people directly, and have the potential to stop commerce. The H1N1 virus presented us with the first pandemic of the 21st century, but how well did the world respond? This crosssector conversation engages academics, policy-makers, social entrepreneurs, and audience members around what worked, what didn’t, and what can be learned about the roles of government, industry, the social sector, and media when it comes to tackling a global threat.